England, 1580. A young Latin tutor--penniless, bullied by a violent father--falls in love with an eccentric young woman: a wild creature who walks her family's estate with a falcon on her shoulder and is known throughout the countryside for her unusual gifts as a healer. Agnes understands plants and potions better than she does people, but once she settles on the Henley Street in Stratford she becomes a fiercely protective mother and a steadfast, centrifugal force in the life of her young husband. His gifts as a writer are just beginning to awaken when their beloved twins, Hamnet and Judith, are afflicted with the bubonic plague, and, devastatingly, one of them succumbs to the illness.